N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Base Information

Chemical Name:N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide
CAS No.:1609487-65-1
Molecular Formula:C₁₇H₁₁ClF₃NO₂
Molecular Weight:353.728
Hs Code.:

Synonyms:N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

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Technology Process of N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

There total 2 articles about N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 69559-40-6
N-(2-benzoyl-4-chlorophenyl)-2,2,2-trifluoroacetamide

: 4301-14-8
acetylenemagnesium bromide

: 1609487-65-1
N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: In tetrahydrofuran; for 3h; Reflux;
DOI:10.1021/ol501048x

Reference yield:

: 719-59-5
5-chloro-2-aminobenzophenone

: 1609487-65-1
N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.17 h / -78 - 20 °C

2: tetrahydrofuran / 3 h / Reflux

With triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol501048x