69559-40-6

Upstream product

• 108-86-1 bromobenzene 
• 635-21-2 5-chloroanthranilic acid 
• 150879-48-4 N-methyl-N-methyloxy-2-amino-5-chlorobenzamide 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 80171-08-0 syn-5-chloro-2-trifluoroacetamidobenzophenone methylimine 
• 1609487-65-1 N-(4-chloro-2-(1-hydroxy-1-phenylprop-2-yn-1-yl)phenyl)-2,2,2-trifluoroacetamide 
• 5900-51-6 6-chloro-3,4-dihydro-3-methyl-4-phenyl-2(1H)-quinazolinone 
• 80171-00-2 6-chloro-3,4-dihydro-3-(2-morpholinoethyl)-4-phenyl-2-trifluoromethylquinazoline 
• 80170-93-0 5-chloro-N-ethyl-2-trifluoroacetamidobenzhydrylamine 
• 80170-99-6 6-chloro-3,4-dihydro-3-ethyl-4-phenyl-2-trifluoromethylquinazoline 
• 80170-91-8 5-chloro-N-methyl-2-trichloroacetamidobenzhydrylamine 
• 80170-98-5 6-chloro-3,4-dihydro-3-methyl-4-phenyl-2-trifluoromethylquinazoline 
• 80170-74-7 1-acetyl-6-chloro-3,4-dihydro-3-methyl-4-phenyl-2(1H)-quinazolinone 
• 80170-90-7 2-amino-5-chloro-N-methylbenzhydrylamine 
• 573692-40-7 (2,3-diamino-5-chloro-phenyl)-phenyl-methanone 
• 4937-83-1 (2-amino-5-chloro-3-nitrophenyl)phenyl-methanone 
• 573692-72-5 N-(2-benzoyl-4-chloro-6-nitrophenyl)-2,2,2-trifluoroacetamide 
• 1428245-05-9 N-(4-chloro-2-(2-hydroxybenzoyl)phenyl)-2,2,2-trifluoroacetamide 

Relevant academic research and scientific papers

Asymmetric Synthesis of Hydroquinazolines Bearing C4-Tetrasubstituted Stereocenters via Kinetic Resolution of α-Tertiary Amines

A novel protocol for asymmetric synthesis of hydroquinazolines bearing C4-tetrasubstituted stereocenters has been achieved through kinetic resolution of 2-amido α-tertiary benzylamines via chiral phosphoric acid catalyzed intramolecular dehydrative cyclizations. This method gave access to both α-tertiary benzylamines and hydroquinazolines with broad scope and high enantioselectivities. An intriguing restricted rotation of the C-N bond was observed for hydroquinazoline products bearing C4-tetrasubstituted stereocenters.

Palladium-catalyzed tandem intramolecular oxy/amino-palladation/isocyanide insertion: Synthesis of α-benzofuranyl/indolylacetamides

A novel palladium-catalyzed approach to 2-benzofuranyl/indolylacetamides from 1-(o-hydroxy/aminophenyl)propargylic alcohols and isocyanides is described. The reaction proceeds through a cascade that includes oxy/aminopalladation, isocyanide insertion, and 1,4-hydroxyl migration. No oxidant or ligand is needed to promote the cascade, and the reactions are carried out under mild conditions to afford the products through high functional tolerance.

Synthesis and SAR of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones related to licostinel (Acea 1021) as NMDA/glycine site antagonists

A series of novel di- and trisubstituted 1,4-dihydroquinoxaline-2,3-diones (QXs) related to licostinel (Acea 1021) was synthesized and evaluated as antagonists for the glycine site of the N-methyl-D-asparate (NMDA) receptor. The in vitro potency of these