(S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

Base Information

Chemical Name:(S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one
CAS No.:618096-34-7
Molecular Formula:C₂₅H₂₈F₆N₂O₂
Molecular Weight:502.5
Hs Code.:

Synonyms:(S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

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Chemical Property of (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

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Technology Process of (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

There total 6 articles about (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 345579-89-7
(R)-2-tert-butyl-3-methyl-(S)-5-phenylimidazolidin-4-one

: 530441-95-3
(R)-1-(1-(bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene

: 618096-34-7
(S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

Guidance literature:: (R)-2-tert-butyl-3-methyl-(S)-5-phenylimidazolidin-4-one; With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; at -78 ℃; for 0.833333h;

(R)-1-(1-(bromomethoxy)ethyl)-3,5-bis(trifluoromethyl)benzene; In tetrahydrofuran; cyclohexane; at -78 ℃; for 2h;
DOI:10.1021/ol030104p

Reference yield:

: 30071-93-3
3,5-bis(trifluoromethyl)phenyl methyl ketone

: 618096-34-7
(S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 98.7 percent / chiral oxazaborolidine; BH₃*SMe₂ / CH₂Cl₂; toluene / -20 °C

2.1: Heating

2.2: hydrogen bromide

3.1: LDA*THF / tetrahydrofuran; cyclohexane / 0.83 h / -78 °C

3.2: 55 percent / tetrahydrofuran; cyclohexane / 2 h / -78 °C

With dimethylsulfide borane complex; chiral oxazaborolidine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; cyclohexane; toluene;
DOI:10.1021/ol030104p

Reference yield:

: 129213-83-8
(S)-2-amino-N-methyl-2-phenylacetamide

: 618096-34-7
(S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: pentane / 19 h

1.2: 49 percent / hydrochloric acid / methanol / 0 - 20 °C

2.1: LDA*THF / tetrahydrofuran; cyclohexane / 0.83 h / -78 °C

2.2: 55 percent / tetrahydrofuran; cyclohexane / 2 h / -78 °C

With lithium diisopropyl amide; In tetrahydrofuran; cyclohexane; pentane;
DOI:10.1021/ol030104p