345579-89-7

Upstream product

• 129213-83-8 (S)-2-amino-N-methyl-2-phenylacetamide 
• 630-19-3 pivalaldehyde 
• 15028-39-4 L-2-phenylglycine methyl ester hydrochloride 

Downstream Products

• 1313492-32-8 (2S,5S)-2-tert-butyl-3-methyl-5-phenyl-1-(2,2,2-trifluoroethanoyl)imidazolidin-4-one 
• 1276111-20-6 (2R,5R)-2-tert-butyl-3-methyl-5-phenyl-4-imidazolidinone trichloroacetic acid salt 
• 345580-18-9 (S)-2-amino-3-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-N-methyl-2-phenylpropionamide 
• 618096-34-7 (S)-5-[(R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxymethyl]-(R)-2-tert-butyl-3-methyl-5-phenylimidazolidin-4-one 

Relevant academic research and scientific papers

Enantioselective α-arylation of aldehydes via the productive merger of iodonium salts and organocatalysis

The enantioselective α-arylation of aldehydes has been accomplished using diaryliodonium salts and a combination of copper and organic catalysts. These mild catalytic conditions provide a new strategy for the enantioselective construction and retention of enolizable α-formyl benzylic stereocenters, a valuable synthon for the production of medicinal agents. As one example, this new asymmetric protocol has been applied to the rapid synthesis of (S)-ketoprofen, a commercially successful oral and topical analgesic.

Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists

(Equation presented) A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.