2,5-dibromobenzoic acid ethyl ester

Base Information

• Chemical Name: 2,5-dibromobenzoic acid ethyl ester
• CAS No.: 76008-76-9
• Molecular Formula: C₉H₈Br₂O₂
• Molecular Weight: 307.969
• Mol file: 76008-76-9.mol

Synonyms:2,5-dibromobenzoic acid ethyl ester

Chemical Property of 2,5-dibromobenzoic acid ethyl ester

Chemical Property:

Purity/Quality:

2,5-Dibromo-benzoicacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dibromobenzoic acid ethyl ester

There total 5 articles about 2,5-dibromobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

benzoic acid ethyl ester (93-89-0,99341-95-4) → 2,5-dibromobenzoic acid ethyl ester (76008-76-9)

Guidance literature:

With bromine fluoride; In ethanol; chloroform; at -40 ℃; for 0.5h;

DOI:10.1021/jo00258a030

Reference yield: 71.0%

ethyl 3-bromobenzoate (24398-88-7) → 2,5-dibromobenzoic acid ethyl ester (76008-76-9)

Guidance literature:

With sodium persulfate; N-Bromosuccinimide; trifluorormethanesulfonic acid; palladium diacetate; In 1,2-dichloro-ethane; at 90 ℃; for 5h; regioselective reaction; Sealed tube;

DOI:10.1002/anie.201300176

Reference yield: 5.0%

benzoic acid ethyl ester (93-89-0,99341-95-4) → ethyl 3-bromobenzoate (24398-88-7) + 2,5-dibromobenzoic acid ethyl ester (76008-76-9)

Guidance literature:

With bromine fluoride; In ethanol; chloroform; at -40 ℃; for 2h;

DOI:10.1021/jo00258a030

upstream raw materials:

ethanol

2,5-dibromobenzoic acid

benzoic acid ethyl ester

2-bromobenzoic-acid

Downstream raw materials:

(2,5-dibromophenyl)methanol

7-bromoisochroman-4-one

1,4-dibromo-2-(bromomethyl)benzene

Refernces

• 1、 Rozen, Shlomo,Brand, Michael,Lidor, Rami. "Aromatic Bromination Using BrF with No Friedel-Crafts Catalyst". . p. 5545 - 5547. Retrieved 2007/10/02.