1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate
CAS No.:884510-91-2
Molecular Formula:C₁₇H₂₃NO₃
Molecular Weight:289.375
Hs Code.:

Synonyms:1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

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Chemical Property of 1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

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Technology Process of 1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

There total 2 articles about 1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 100-58-3
phenylmagnesium bromide

: 189442-78-2
(±)-tert-butyl 3-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate

: 884510-91-2
1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

Guidance literature:: In tetrahydrofuran; at -78 - 20 ℃;
DOI:10.1016/j.bmcl.2009.01.012

Reference yield:

: 71381-75-4,88495-54-9,84358-12-3
N-(tert-butyloxycarbonyl)nipecotic acid

: 884510-91-2
1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

2: tetrahydrofuran / 2.5 h / -78 - 20 °C / Inert atmosphere

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 100.0%

: 884510-91-2
1,1-dimethylethyl 3-benzoyl-1-piperidinecarboxylate

: 1,1-dimethylethyl (3RS)-3-[(1RS)-hydroxyphenylmethyl]-1-piperidinecarboxylate

Guidance literature:: With RuCl₂(BIPHEP)(DMEN); potassium tert-butylate; hydrogen; In isopropyl alcohol; at 25 ℃; for 20h; under 7600.51 Torr; optical yield given as %de; diastereoselective reaction; Autoclave;
DOI:10.1002/adsc.201100398