(4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE

Base Information

• Chemical Name: (4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE
• CAS No.: 33829-87-7
• Molecular Formula: C₁₁H₁₀ClNO
• Molecular Weight: 207.659
• Mol file: 33829-87-7.mol

Synonyms:4-chloro-N-(furan-2-yl-methyl)aniline

Chemical Property of (4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE

Chemical Property:

• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

4-chloro-N-(furan-2-ylmethyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE

There total 8 articles about (4-CHLORO-PHENYL)-FURAN-2-YLMETHYL-AMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-furylmethylene)-p-chloraniline (13533-22-7) → 4-chloro-N-(furan-2-yl-methyl)aniline (33829-87-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; Heating;

DOI:10.1016/j.bmc.2005.10.036

Reference yield: 93.0%

furfural (98-01-1) + 4-chloro-aniline (106-47-8) → 4-chloro-N-(furan-2-yl-methyl)aniline (33829-87-7)

Guidance literature:

furfural; 4-chloro-aniline; With zinc(II) chloride; In methanol; at 20 ℃; for 3h; Inert atmosphere;

With methanol; sodium tetrahydroborate; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b01267

Reference yield: 87.0%

(2-furyl)methyl alcohol (98-00-0,25212-86-6,93793-62-5) + 4-chloro-aniline (106-47-8) → 4-chloro-N-(furan-2-yl-methyl)aniline (33829-87-7)

Guidance literature:

(2-furyl)methyl alcohol; 4-chloro-aniline; With (1,3-bis(2,6-di-iso-propylphenyl)-4,5-dihydroimidazol-2-ylidene) copper chloride; potassium tert-butylate; oxygen; In tetrahydrofuran; at 20 ℃; for 6h; Molecular sieve;

With (1,3-bis(2,6-di-iso-propylphenyl)-4,5-dihydroimidazol-2-ylidene) copper chloride; In tetrahydrofuran; at 20 ℃; for 8h; Molecular sieve;

DOI:10.1021/acs.orglett.5b02756

upstream raw materials:

N-(2-furylmethylene)-p-chloraniline

furfural

4-chloro-aniline

(2-furyl)methyl alcohol

Downstream raw materials:

1-(4-Chloro-phenyl)-1-furan-2-ylmethyl-3-phenyl-thiourea