(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

Base Information

Chemical Name:(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid
CAS No.:406161-90-8
Molecular Formula:C₂₄H₁₇Cl₂NO₃
Molecular Weight:438.31
Hs Code.:

Synonyms:(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

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Chemical Property of (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

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Technology Process of (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

There total 2 articles about (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 406161-89-5
(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetonitrile

: 406161-90-8
(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

Guidance literature:: With acetic acid; at 110 ℃; for 3h;
DOI:10.1016/j.bmcl.2003.09.043

Reference yield:

: 192187-33-0
R₁₀₄₂₀₉

: 406161-90-8
(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / t-BuOK / 1,2-dimethoxy-ethane; dimethylformamide; 2-methyl-propan-2-ol / 3 h / 20 °C

2: 92 percent / H₂SOH; AcOH / 3 h / 110 °C

With potassium tert-butylate; acetic acid; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1016/j.bmcl.2003.09.043

Reference yield: 50.0%

: 6610-29-3
4-methylthiosemicarbazide

: 406161-90-8
(4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid

: 406161-91-9
C₂₆H₂₂Cl₂N₄O₂S

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2003.09.043