406161-89-5

Basic information

• Product Name: 6-Quinolineacetonitrile, 4-(3-chlorophenyl)-a-(4-chlorophenyl)-1,2-dihydro-1-methyl-2-oxo-
• CAS NO: 406161-89-5
• Molecular Formula: C24H16Cl2N2O
• Molecular Weight: 419.31
• Mol File: 406161-89-5.mol

Chemical Properties

• CAS DataBase Reference: 6-Quinolineacetonitrile, 4-(3-chlorophenyl)-a-(4-chlorophenyl)-1,2-dihydro-1-methyl-2-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Quinolineacetonitrile, 4-(3-chlorophenyl)-a-(4-chlorophenyl)-1,2-dihydro-1-methyl-2-oxo-(406161-89-5)
• EPA Substance Registry System: 6-Quinolineacetonitrile, 4-(3-chlorophenyl)-a-(4-chlorophenyl)-1,2-dihydro-1-methyl-2-oxo-(406161-89-5)

Safety Data

• Hazardous Substances Data: 406161-89-5(Hazardous Substances Data)

Upstream product

• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 192187-33-0 R₁₀₄₂₀₉ 

Downstream Products

• 406161-91-9 C₂₆H₂₂Cl₂N₄O₂S 
• 654074-93-8 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(5-mercapto-4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 406161-92-0 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl-5-methylsulfanyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 406162-54-7 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 654074-95-0 6-[chloro(4-chlorophenyl)(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone 
• 406162-47-8 4-(3-chlorophenyl)-6-[(4-chlorophenyl)(4-methyl-4H-1,2,4-triazol-3-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 654074-97-2 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(1-methyl-1H-tetrazol-5-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 654074-96-1 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(1H-tetrazol-5-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 406161-90-8 (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid 

Relevant articles and documents

4-Methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the Farnesyltransferase inhibitor ZARNESTRA

Replacement of the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA series by a 4-methyl-1,2,4-triazol-3-yl group gave us compounds with similar structure-activity relationship profiles showing that this triazole is potentially a good surrogate to imidazole for farnesyltransferase inhibition.