192187-33-0

Basic information

• Product Name: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one
• CAS NO: 192187-33-0
• Molecular Formula: C₂₃H₁₅Cl₂NO₂
• Molecular Weight: 408.2767
• Mol File: 192187-33-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 574.648°C at 760 mmHg
• Flash Point: 301.336°C
• Density: 1.355g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.654
• CAS DataBase Reference: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one(192187-33-0)
• EPA Substance Registry System: 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methylquinolin-2(1H)-one(192187-33-0)

Safety Data

• Hazardous Substances Data: 192187-33-0(Hazardous Substances Data)

Upstream product

• 192187-32-9 R₁₀₁₇₆₃ 
• 74-88-4 methyl iodide 
• 405548-67-6 N-[2-(3-chlorobenzoyl)-4-(4-chlorobenzoyl)phenyl]acetamide 
• 406162-21-8 (4-chlorophenyl)-[4-(3-chlorophenyl)-2-methoxyquinolin-6-yl]methanone 
• 190898-77-2 3-(3-chlorophenyl)-5-[2-(4-chlorophenyl)-1,3-dioxolan-2-yl]-2,1-benzisoxazole 
• 190898-78-3 [2-amino-5-(4-chlorobenzoyl)phenyl](3-chlorophenyl)-methanone 
• 190898-64-7 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane 
• 406161-72-6 N-[4-bromo-2-(3-chlorobenzoyl)phenyl]acetamide 
• 280143-23-9 6-bromo-2-chloro-4-(3-chlorophenyl)quinoline 
• 190898-86-3 6-bromo-4-(3-chloro-phenyl)-2-methoxy-quinoline 
• 192187-30-7 4-(3-chlorophenyl)-3,4-dihydro-2(1H)-quinolinone 
• 288391-73-1 5-Bromo-3-(3-chloro-phenyl)-benzo[c]isoxazole 
• 74-11-3 para-chlorobenzoic acid 
• 65247-25-8 (2-amino-5-bromo-phenyl)-(3-chloro-phenyl)-methanone 

Downstream Products

• 192185-68-5 6-[amino(4-chlorophenyl)-1-methyl-1H-imidazol-5-ylmethyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone 
• 192185-72-1 tipifarnib 
• 406162-93-4 4-(3-chlorophenyl)-6-[(4-chlorophenyl)(4-chloro-3-pyridinyl)hydroxymethyl]-1-methyl-2(1H)-quinolinone 
• 406161-91-9 C₂₆H₂₂Cl₂N₄O₂S 
• 654074-93-8 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(5-mercapto-4-methyl-4H-[1,2,4]triazol-3-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 654074-97-2 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(1-methyl-1H-tetrazol-5-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 654074-96-1 4-(3-chloro-phenyl)-6-[(4-chloro-phenyl)-(1H-tetrazol-5-yl)-methyl]-1-methyl-1H-quinolin-2-one 
• 406161-90-8 (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetic acid 
• 192185-51-6 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone 
• 406161-89-5 (4-chloro-phenyl)-[4-(3-chloro-phenyl)-1-methyl-2-oxo-1,2-dihydro-quinolin-6-yl]-acetonitrile 

Relevant articles and documents

Synthesis Routes Towards the Farnesyl Protein Transferase Inhibitor ZARNESTRA

The discovery that post-translational farnesylation of Ras oncoprotein was an essential step in exercising its biological effect led to the design of farnesyl protein transferase inhibitors (FTIs) in order to control growth of tumors bearing Ras mutations. Pre-clinical studies on murine models have confirmed their inhibitory effect on tumor growth and enabled clinical development. R115777 (ZARNESTRA) is currently undergoing clinical evaluation and recent studies have confirmed its antitumor potential and low toxicity. We wish to describe here the chemical synthesis routes that our group have developed to access ZARNESTRA. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.

Farnesyl protein transferase inhibiting (imidazol-5-yl)methyl-2-quionlinone derivatives

PCT No. PCT/EP96/04515 Sec. 371 Date May 26, 1998 Sec. 102(e) Date May 26, 1998 PCT Filed Oct. 16, 1996 PCT Pub. No. WO97/21701 PCT Pub. Date Jun. 19, 1997This invention comprises the novel compounds of formula (I) wherein the dotted line represents an op