N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester

Base Information

• Chemical Name: N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester
• CAS No.: 283611-42-7
• Molecular Formula: C₁₆H₁₆N₂O₆S
• Molecular Weight: 364.379
• Mol file: 283611-42-7.mol

Synonyms:N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester

Chemical Property of N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester

There total 4 articles about N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

dimethyl sulfate (77-78-1) + N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester (283611-27-8) → N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester (283611-42-7)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jo050477z

Reference yield:

L-2-phenylglycine methyl ester hydrochloride (15028-39-4,13226-98-7) → N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester (283611-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / triethylamine / CH₂Cl₂

2: 98 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N-methyl-N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester (283611-42-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / triethylamine / CH₂Cl₂

2: 98 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

upstream raw materials:

N-(o-nitrobenzenesulfonyl)-L-phenylglycine methyl ester

methyl iodide

dimethyl sulfate

L-2-phenylglycine methyl ester hydrochloride

Downstream raw materials:

N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-L-phenylglycine