5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione
CAS No.:1590381-01-3
Molecular Formula:C₃₆H₃₉FN₂O₇
Molecular Weight:630.713
Hs Code.:

5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

Synonyms:5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

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Chemical Property of 5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

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Technology Process of 5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

There total 4 articles about 5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 5-fluoro-1-[(3aR,4R,6R,6aR)-3a,4,6,6a-tetrahydro-6-(hydroxymethyl)-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 1590381-01-3
5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: In pyridine; at 20 ℃; for 18h; Inert atmosphere;

Reference yield: 91.0%

: 5-fluoro-1-[(3aR,4R,6R,6aR)-3a,4,6,6a-tetrahydro-6-(hydroxymethyl)-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

: 14470-28-1
mono-4-methoxytrityl chloride

: 1590381-01-3
5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With pyridine; at 20 ℃; for 18h; Inert atmosphere;
DOI:10.1002/cbdv.201300107

Reference yield:

: 123-19-3
4-heptanone

: 1590381-01-3
5-fluoro-1-[ (3aR,4R,6R,6aR)-tetrahydro-6-{[(4-methoxyphenyl)(diphenyl)methoxy]methyl}-2,2-dipropylfuro[3,4-d][1,3]dioxol-4-yl]pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; orthoformic acid triethyl ester / N,N-dimethyl-formamide; 1,4-dioxane / 22 h / 20 °C

2: pyridine / 18 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; orthoformic acid triethyl ester; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1002/cbdv.201300107