2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

Base Information

Chemical Name:2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime
CAS No.:1461755-64-5
Molecular Formula:C₂₇H₂₈N₂O₇
Molecular Weight:492.529
Hs Code.:

Synonyms:2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

Suppliers and Price of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

There total 4 articles about 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.17%

: 35388-10-4
3,4,5-trihydroxybenzoyl chloride

: 1461755-51-0
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one oxime

: 1461755-64-5
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

Guidance literature:: 2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one oxime; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.416667h;

3,4,5-trihydroxybenzoyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;
DOI:10.1007/s00044-013-0793-z

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 1461755-64-5
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium acetate / ethanol / Heating

2.1: potassium carbonate / acetone / 4 h / Reflux

3.1: sodium acetate trihydrate / ethanol / 0.25 h / Heating

3.2: 2 h / Reflux

4.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.42 h / 20 °C

4.2: 8 h / 20 °C

With potassium tert-butylate; ammonium acetate; sodium acetate trihydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone; 1.1: |Mannich Aminomethylation;
DOI:10.1007/s00044-013-0793-z

Reference yield:

: 199285-47-7
2,6-bis(4-methoxyphenyl)piperidin-4-one

: 1461755-64-5
2,6-bis(4-methoxyphenyl)-1-methylpiperidin-4-one O-3,4,5-trihydroxybenzoyloxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: sodium acetate trihydrate / ethanol / 0.25 h / Heating

2.2: 2 h / Reflux

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.42 h / 20 °C

3.2: 8 h / 20 °C

With potassium tert-butylate; sodium acetate trihydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1007/s00044-013-0793-z