ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate

Base Information

• Chemical Name: ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate
• CAS No.: 1411734-52-5
• Molecular Formula: C₂₀H₂₁ClF₂N₄O₄S
• Molecular Weight: 486.927

Synonyms:ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate

Chemical Property of ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate

There total 5 articles about ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-chloro-2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidine 6,6-dioxide (885039-08-7) + 1-(Ethoxycarbonylmethyl)piperazine (40004-08-8) → ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate (1411734-52-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 70 ℃; for 15h;

DOI:10.1016/j.bmc.2012.08.054

Reference yield:

4-chloro-2,5-difluorobenzamidine (764648-44-4) → ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate (1411734-52-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium methylate / methanol / 20 - 50 °C

2: trichlorophosphate / 3 h / Reflux

3: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / acetonitrile / 15 h / 70 °C

With sodium methylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In methanol; chloroform; acetonitrile;

DOI:10.1016/j.bmc.2012.08.054

Reference yield:

4-chloro-2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidine (885038-88-0) → ethyl {4-[2-(4-chloro-2,5-difluorophenyl)-6,6-dioxido-5,7-dihydrothieno[3,4-d]pyrimidin-4-yl]piperazin-1-yl}acetate (1411734-52-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform / 1 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 15 h / 70 °C

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In chloroform; acetonitrile;

DOI:10.1016/j.bmc.2012.08.054

upstream raw materials:

4-chloro-2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidine 6,6-dioxide

1-(Ethoxycarbonylmethyl)piperazine

2-(4-chloro-2,5-difluorophenyl)-5,7-dihydrothieno[3,4-d]pyrimidin-4(3H)-one

methyl 4-oxotetrahydrothiophene-3-carboxylate

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