2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester

Base Information

• Chemical Name: 2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester
• CAS No.: 936640-79-8
• Molecular Formula: C₃₂H₃₆N₂O₆
• Molecular Weight: 544.648
• Mol file: 936640-79-8.mol

Synonyms:2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester

Chemical Property of 2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of 2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester

There total 1 articles about 2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-hex-2-en-1-one + malonic acid dibenzyl ester (15014-25-2) → 2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester (936640-79-8) + 2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester

Guidance literature:

With lanthanum(III) isopropoxide; 1,1,1,3',3',3'-hexafluoro-propanol; (S,S)-Ph-linked-BINOL; In 1,2-dimethoxyethane; at -20 ℃; for 40h;

DOI:10.1016/j.tetlet.2007.02.112

Reference yield: 96.0%

2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester (936640-79-8) → 2-benzyloxycarbonyl-3-propyl-pentanedioic acid 1-benzyl ester 5-methyl ester

Guidance literature:

With erbium(III) triflate; In methanol; acetonitrile; at 25 ℃; for 24h;

DOI:10.1016/j.tetlet.2007.02.112

Reference yield: 92.0%

2-(1-{2-oxo-2-[2-(pyrrolidine-1-carbonyl)-pyrrol-1-yl]-ethyl}-butyl)-malonic acid dibenzyl ester (936640-79-8) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → 2-{1-[(methoxy-methyl-carbamoyl)-methyl]-butyl}-malonic acid dibenzyl ester

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 ℃; for 22h;

DOI:10.1016/j.tetlet.2007.02.112

upstream raw materials:

malonic acid dibenzyl ester