(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate

Base Information

• Chemical Name: (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate
• CAS No.: 1279724-00-3
• Molecular Formula: C₂₆H₄₀N₂O₂
• Molecular Weight: 412.616
• Mol file: 1279724-00-3.mol

Synonyms:(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate

Chemical Property of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate

There total 1 articles about (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

8-iodooct-1-yne (60754-50-9) + (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-2-(pyridin-2-yl)ethylcarbamate (1248569-13-2) → (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate (1279724-00-3)

Guidance literature:

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-2-(pyridin-2-yl)ethylcarbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

8-iodooct-1-yne; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.12.057

Reference yield:

tert-butyl 2-amino-4-(5-azidopentyl)-1H-imidazole-1-carboxylate (1279724-01-4) + (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate (1279724-00-3) → tert-butyl 2-amino-4-(5-(4-(6-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)(2-(pyridin-2-yl)ethyl)amino)hexyl)-1H-1,2,3-triazol-1-yl)pentyl)-1H-imidazole-1-carboxylate (1279724-17-2)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In ethanol; dichloromethane; water; at 20 ℃;

DOI:10.1016/j.bmcl.2010.12.057

Reference yield:

tert-butyl 2-amino-4-(6-azidohexyl)-1H-imidazole-1-carboxylate (1279724-02-5) + (1R,2S,5R)-2-isopropyl-5-methylcyclohexyl oct-7-ynyl(2-(pyridin-2-yl)ethyl)carbamate (1279724-00-3) → tert-butyl 2-amino-4-(6-(4-(6-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)(2-(pyridin-2-yl)ethyl)amino)hexyl)-1H-1,2,3-triazol-1-yl)hexyl)-1H-imidazole-1-carboxylate (1279724-19-4)

Guidance literature:

With copper(II) sulfate; sodium L-ascorbate; In ethanol; dichloromethane; water; at 20 ℃;

DOI:10.1016/j.bmcl.2010.12.057

upstream raw materials:

8-iodooct-1-yne

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl-2-(pyridin-2-yl)ethylcarbamate

Downstream raw materials:

tert-butyl 2-amino-4-(5-(4-(6-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)(2-(pyridin-2-yl)ethyl)amino)hexyl)-1H-1,2,3-triazol-1-yl)pentyl)-1H-imidazole-1-carboxylate

tert-butyl 2-amino-4-(6-(4-(6-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)(2-(pyridin-2-yl)ethyl)amino)hexyl)-1H-1,2,3-triazol-1-yl)hexyl)-1H-imidazole-1-carboxylate

tert-butyl 2-amino-4-(7-(4-(6-((((1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy)carbonyl)(2-(pyridin-2-yl)ethyl)amino)hexyl)-1H-1,2,3-triazol-1-yl)heptyl)-1H-imidazole-1-carboxylate

(1R,2S,5R)-2-isopropyl-5-methylcyclohexyl 6-(1-(5-(2-amino-1H-imidazol-4-yl)pentyl)-1H-1,2,3-triazol-4-yl)hexyl(2-(pyridin-2-yl)ethyl)carbamate