tert-butyl {3-fluoro-4-[(5-nitropyridin- 2-yl)oxy]phenyl}carbamate

Base Information

• Chemical Name: tert-butyl {3-fluoro-4-[(5-nitropyridin- 2-yl)oxy]phenyl}carbamate
• CAS No.: 1195781-41-9
• Molecular Formula: C₁₆H₁₆FN₃O₅
• Molecular Weight: 349.319
• Mol file: 1195781-41-9.mol

Synonyms:tert-butyl {3-fluoro-4-[(5-nitropyridin-2-yl)oxy]phenyl}carbamate

Chemical Property of tert-butyl {3-fluoro-4-[(5-nitropyridin- 2-yl)oxy]phenyl}carbamate

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl {3-fluoro-4-[(5-nitropyridin- 2-yl)oxy]phenyl}carbamate

There total 1 articles about tert-butyl {3-fluoro-4-[(5-nitropyridin- 2-yl)oxy]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

N-(3-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester (859537-27-2) + 2-chloro-5-nitropyridine (4548-45-2) → tert-butyl {3-fluoro-4-[(5-nitropyridin-2-yl)oxy]phenyl}carbamate (1195781-41-9)

Guidance literature:

With caesium carbonate; In dimethyl sulfoxide; at 20 ℃; for 4h;

Reference yield: 90.0%

tert-butyl {3-fluoro-4-[(5-nitropyridin-2-yl)oxy]phenyl}carbamate (1195781-41-9) → tert-butyl {3-fluoro-4-[(5-aminopyridin-2-yl)oxy]phenyl}carbamate (1195781-43-1)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In methanol; at 20 ℃; for 8h;

Reference yield:

tert-butyl {3-fluoro-4-[(5-nitropyridin-2-yl)oxy]phenyl}carbamate (1195781-41-9) → N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide (1195781-47-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen / 5%-palladium/activated carbon / methanol / 8 h / 20 °C

2: bromine / acetic acid / 0 - 20 °C

3: triethylamine / ISOPROPYLAMIDE / 24 h / 20 °C

4: trifluoroacetic acid / methoxybenzene / 2 h / 0 °C

With hydrogen; bromine; triethylamine; trifluoroacetic acid; 5%-palladium/activated carbon; In methanol; ISOPROPYLAMIDE; acetic acid; methoxybenzene;

upstream raw materials:

N-(3-fluoro-4-hydroxyphenyl)carbamic acid tert-butyl ester

2-chloro-5-nitropyridine

Downstream raw materials:

tert-butyl {3-fluoro-4-[(5-aminopyridin-2-yl)oxy]phenyl}carbamate

N-[5-(4-amino-2-fluorophenoxy)[1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

tert-butyl {4-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)oxy]-3-fluorophenyl}carbamate

tert-butyl [4-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-3-fluorophenyl]carbamate