tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

Base Information

Chemical Name:tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate
CAS No.:1598383-52-8
Molecular Formula:C₃₇H₅₃N₅O₅
Molecular Weight:647.858
Hs Code.:

tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

Synonyms:tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

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Chemical Property of tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

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Technology Process of tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

There total 6 articles about tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.4%

: 771579-27-2
3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one

: 1598383-54-0
C₂₉H₄₃N₃O₅

: 1598383-52-8
tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

Guidance literature:: 3-(aminomethyl)-4,6-dimethyl-1,2-dihydropyridin-2-one; C₂₉H₄₃N₃O₅; With triethylamine; In dimethyl sulfoxide; at 20 ℃; for 0.25h;

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dimethyl sulfoxide; at 20 ℃;

Reference yield:

: 1598383-48-2
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)(methyl)amino)cyclohexyl)(ethyl)amino)-2-methylbenzoate

: 1598383-52-8
tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; copper(l) iodide; diisopropylamine / toluene / 5 h / 80 °C / Inert atmosphere; Sealed tube

2.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 0 - 20 °C

3.1: N,N-dimethyl-formamide / 12 h / 20 °C

4.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

5.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

5.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; water; triethylamine; diisopropylamine; triphenylphosphine; sodium hydroxide; In ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 1.1: |Sonogashira Cross-Coupling;

Reference yield:

: 1403258-27-4
methyl 5-bromo-3-(((trans)-4-((tert-butoxycarbonyl)amino)cyclohexyl)-(ethyl)amino)-2-methylbenzoate

: 1598383-52-8
tert-butyl ((trans)-4-((3-(((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)carbamoyl)-2-methyl-5-(3-morpholinoprop-1-yn-1-yl)phenyl)(ethyl)amino)cyclohexyl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 0 - 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine; copper(l) iodide; diisopropylamine / toluene / 5 h / 80 °C / Inert atmosphere; Sealed tube

3.1: triphenylphosphine; carbon tetrabromide / dichloromethane / 4 h / 0 - 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 20 °C

5.1: sodium hydroxide; water / ethanol / 1 h / 60 °C

6.1: triethylamine / dimethyl sulfoxide / 0.25 h / 20 °C

6.2: 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; carbon tetrabromide; water; sodium hydride; triethylamine; diisopropylamine; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 2.1: |Sonogashira Cross-Coupling;