Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate

Base Information

Chemical Name:Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate
CAS No.:74853-06-8
Molecular Formula:C24H25 N3 O3
Molecular Weight:403.481
Hs Code.:
DSSTox Substance ID:DTXSID40359680
Wikidata:Q82140976
Mol file:74853-06-8.mol

Synonyms:74853-06-8;4-{[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl}-carbamic Acid Phenyl Ester;Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate;phenyl[4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]carbamate;phenyl{4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl}carbamate;NUCLEARFASTRED;SCHEMBL2543995;DTXSID40359680;AKOS024286551;FT-0671346;[4-(4-Methoxypiperazine-1-yl)phenyl]carbamic acid phenyl ester;phenyl [4-[4-(4-methoxyphenyl)-1-piperazinyl]phenyl]carbamate;Phenyl {4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl}carbamate;phenyl 4-[4-(4-methoxyphenyl)-1-piperazinyl]phenylcarbamate

Suppliers and Price of Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-{[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl}-carbamicAcidPhenylEster
2g
$ 1455.00

Medical Isotopes, Inc.
4-[[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl]-carbamicAcidPhenylEster
250 mg
$ 840.00

Medical Isotopes, Inc.
4-[[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl]-carbamicAcidPhenylEster
1.25 g
$ 1720.00

American Custom Chemicals Corporation
4-((4-(4-METHYLOXY-PHENYL)-PIPERAZIN-1-YL)-PHENYL)-CARBAMIC ACID PHENYL ESTER 95.00%
2.5G
$ 2255.00

American Custom Chemicals Corporation
4-((4-(4-METHYLOXY-PHENYL)-PIPERAZIN-1-YL)-PHENYL)-CARBAMIC ACID PHENYL ESTER 95.00%
250MG
$ 779.63

Total 7 raw suppliers

Chemical Property of Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate

Chemical Property:

Melting Point:184-188 °C (decomp)
Boiling Point:586.2±50.0 °C(Predicted)
PKA:12.79±0.70(Predicted)
PSA：54.04000
Density:1.237±0.06 g/cm3(Predicted)
LogP:4.83570
Storage Temp.:-20°C Freezer
Solubility.:DMF (Slightly), DMSO (Slightly)
XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:403.18959167
Heavy Atom Count:30
Complexity:516

Purity/Quality:

99% ^*data from raw suppliers

4-{[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl}-carbamicAcidPhenylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)N2CCN(CC2)C3=CC=C(C=C3)NC(=O)OC4=CC=CC=C4
Uses 4-{[4-(4-Methyloxy-phenyl)-piperazin-1-yl]-phenyl}-carbamic Acid Phenyl Ester (cas# 74853-06-8) is a compound useful in organic synthesis.

Technology Process of Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate

There total 7 articles about Phenyl N-[4-[4-(4-methoxyphenyl)piperazin-1-yl]phenyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 74852-62-3
4-[4-(4-methoxy-phenyl)-piperazin-1-yl]-phenylamine

: 1885-14-9
phenyl chloroformate

: 74853-06-8
phenyl (4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0494772

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 74853-06-8
phenyl (4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / K₂CO₃ / dimethylsulfoxide / 120 °C

2: 74 percent / H₂, thiophene / 5percent Pd/C / 2-methoxy-ethanol; methanol / 50 °C / Heating

3: 61 percent / pyridine / CHCl₃ / 3 h

With thiophene; pyridine; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; chloroform; 2-methoxy-ethanol; dimethyl sulfoxide;
DOI:10.1021/jm00373a015

Reference yield:

: 100-00-5
4-chlorobenzonitrile

: 74853-06-8
phenyl (4-(4-(4-methoxyphenyl)piperazin-1-yl)phenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 12 h / 160 °C / Inert atmosphere

2: hydrazine hydrate; palladium 10% on activated carbon / ethanol / 3.5 h / Reflux; Inert atmosphere

3: pyridine / chloroform / 0 - 20 °C / Inert atmosphere

With pyridine; palladium 10% on activated carbon; potassium carbonate; hydrazine hydrate; In ethanol; chloroform; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.5b01718