1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate
CAS No.:1186627-30-4
Molecular Formula:C₁₉H₂₅Cl₂NO₅S
Molecular Weight:450.383
Hs Code.:

Synonyms:1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

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Chemical Property of 1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

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Technology Process of 1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

There total 8 articles about 1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1186627-28-0
1,1-dimethylethyl 6-(3,4-dichlorophenyl)-1-(hydroxymethyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1186627-30-4
1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 1013097-84-1
dimethyl 2-(3,4-dichlorophenyl)-2-{2-[(methylsulfonyl)oxy]ethyl}-1,1-cyclopropanedicarboxylate

: 1186627-30-4
1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: ammonia / methanol / 75 °C / 1520.1 Torr

2: borane-THF / tetrahydrofuran / 5 °C / Reflux

3: 20 °C

4: chiral column Chiralpack AD-H / hexane; isopropyl alcohol / Resolution of racemate

5: triethylamine / dichloromethane / 0 - 20 °C

With borane-THF; ammonia; triethylamine; chiral column Chiralpack AD-H; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol;

Reference yield:

: 1013097-83-0
3-(3,4-dichlorophenyl)-3-buten-1-yl methanesulfonate

: 1186627-30-4
1,1-dimethylethyl (1R,6S)-6-(3,4-dichlorophenyl)-1-{[(methylsulfonyl)oxy]methyl}-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: dirhodium(II) tetracarboxylate / chlorobenzene / 2.5 h / 65 - 67 °C

2: ammonia / methanol / 75 °C / 1520.1 Torr

3: borane-THF / tetrahydrofuran / 5 °C / Reflux

4: 20 °C

5: chiral column Chiralpack AD-H / hexane; isopropyl alcohol / Resolution of racemate

6: triethylamine / dichloromethane / 0 - 20 °C

With borane-THF; ammonia; triethylamine; dirhodium(II) tetracarboxylate; In tetrahydrofuran; methanol; hexane; dichloromethane; chlorobenzene; isopropyl alcohol;