tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Base Information

Chemical Name:tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate
CAS No.:1403480-59-0
Molecular Formula:C₃₉H₅₁FN₄O₁₀S
Molecular Weight:786.919
Hs Code.:

tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Synonyms:tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Suppliers and Price of tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

There total 10 articles about tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1403480-48-7
tert-butyl but-3-en-1-yl(2-(((2R,3R)-3-((tert-butyldimethylsilyl)oxy)-4-(4-fluoro-N-methylphenylsulfonamido)-2-methylbutyl)((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

: 1403480-59-0
tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 16h;
DOI:10.1021/jm500994n

Reference yield:

: C₃₀H₅₆N₂O₆Si₂

: 1403480-59-0
tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / tetrahydrofuran; methanol; water / 3 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

3: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

4: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 7 h / 20 - 35 °C

6: dmap / tetrahydrofuran / 1 h / Reflux

7: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h

With 2,6-dimethylpyridine; dmap; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500994n

Reference yield:

: 1255212-77-1
tert-butyl ((2R,3S)-2-((tert-butyldimethylsilyl)oxy)-4-(((2S)-1-((4-methoxybenzyl)oxy)propan-2-yl)amino)-3-methyl-4-oxobutyl)(methyl)carbamate

: 1403480-59-0
tert-butyl but-3-en-1-yl(2-(((2R,3R)-4-(4-fluoro-N-methylphenylsulfonamido)-3-hydroxy-2-methylbutyl)((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)carbamoyl)-4-nitrophenyl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1: 2,6-dimethylpyridine / dichloromethane / 3.92 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / tetrahydrofuran; methanol; water / 3 h / 20 °C

3: 2,6-dimethylpyridine / dichloromethane / 18 h / 20 °C

4: dimethylsulfide borane complex / tetrahydrofuran / 6.25 h / 0 - 65 °C / Inert atmosphere

5: triethylamine / dichloromethane / 3.5 h / 0 - 20 °C

6: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 7 h / 20 - 35 °C

7: dmap / tetrahydrofuran / 1 h / Reflux

8: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h

With 2,6-dimethylpyridine; dmap; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm500994n