triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

Base Information

Chemical Name:triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate
CAS No.:1277116-21-8
Molecular Formula:C₃₆H₅₃FO₅Si₂
Molecular Weight:640.983
Hs Code.:

Synonyms:triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

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Technology Process of triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

There total 5 articles about triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1277116-18-3
triisopropylsilyl 4-(5-formylfuran-2-yl)-2-(triisopropylsilyloxy)benzoate

: 352-13-6
4-flourophenylmagnesium bromide

: 1277116-21-8
triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 1h;
DOI:10.1002/cmdc.201000510

Reference yield:

: 436088-45-8
4-(5-formylfuran-2-yl)-2-hydroxybenzoic acid

: 1277116-21-8
triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 0 - 60 °C

2: tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201000510

Reference yield:

: 1277116-14-9
4-(5-formylfuran-2-yl)-2-hydroxybenzoate methyl ester

: 1277116-21-8
triisopropylsilyl 4-(5-((4-fluorophenyl)(hydroxy)methyl)furan-2-yl)-2-(triisopropylsilyloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / methanol / Reflux

2: 1H-imidazole / N,N-dimethyl-formamide / 0 - 60 °C

3: tetrahydrofuran / 1 h / -78 °C

With 1H-imidazole; water; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201000510