Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester

Base Information

• Chemical Name: Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester
• CAS No.: 102152-59-0
• Molecular Formula: C₅₇H₉₀NO₇PS
• Molecular Weight: 964.384

Synonyms:Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester

Chemical Property of Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester

There total 4 articles about Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-phosphanyloxy}-ethyl ester → Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester (102152-59-0)

Guidance literature:

With sulfur; In toluene; for 10h; Ambient temperature;

DOI:10.1021/jo00362a035

Reference yield:

N-tritylethanolamine (24070-16-4) → Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester (102152-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tetrazole / 1.) vacuum, 1 h, 2.) CH₃CN, THF, 30 min

2: S₈ / toluene / 10 h / Ambient temperature

With 1H-tetrazole; sulfur; In toluene;

DOI:10.1021/jo00362a035

Reference yield:

Hexadecanoic acid (R)-2-(diisopropylamino-methoxy-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester (496808-59-4) → Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-thiophosphoryloxy}-ethyl ester (102152-59-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tetrazole / 1.) vacuum, 1 h, 2.) CH₃CN, THF, 30 min

2: S₈ / toluene / 10 h / Ambient temperature

With 1H-tetrazole; sulfur; In toluene;

DOI:10.1021/jo00362a035

upstream raw materials:

N-tritylethanolamine

Hexadecanoic acid (R)-2-(diisopropylamino-methoxy-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester

1,2-dipalmitoyl-sn-glycerol

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