(4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester

Base Information

• Chemical Name: (4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester
• CAS No.: 1231753-51-7
• Molecular Formula: C₁₉H₂₄O₅
• Molecular Weight: 332.397
• Mol file: 1231753-51-7.mol

Synonyms:(4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester

Chemical Property of (4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester

There total 1 articles about (4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C14H18O3 (1231753-41-5) + propynoic acid ethyl ester (623-47-2) → (4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester (1231753-51-7)

Guidance literature:

propynoic acid ethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

C₁₄H₁₈O₃; In tetrahydrofuran; hexane; at -78 ℃; optical yield given as %de;

DOI:10.1021/ja1033952

Reference yield: 74.0%

(4-benzyloxymethoxy-1-hydroxycyclohexyl)propynoic acid ethyl ester (1231753-51-7) → 7-benzyloxymethoxy-3-oxo-1-oxa-spiro[3.5]nonane-2-carboxylic acid ethyl ester (1231753-68-6)

Guidance literature:

With 4-acetylpyridine N-oxide; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]gold bis(trifluoromethanesulfonyl)imidate; bis(trifluoromethanesulfonyl)amide; In 1,2-dichloro-ethane; at 20 - 40 ℃; for 24h;

DOI:10.1021/ja1033952

upstream raw materials:

C₁₄H₁₈O₃

propynoic acid ethyl ester

Downstream raw materials:

7-benzyloxymethoxy-3-oxo-1-oxa-spiro[3.5]nonane-2-carboxylic acid ethyl ester