2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

Base Information

Chemical Name:2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide
CAS No.:1596335-36-2
Molecular Formula:C₂₃H₂₀ClN₅O₂
Molecular Weight:433.897
Hs Code.:

Synonyms:2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

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Chemical Property of 2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

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Technology Process of 2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

There total 6 articles about 2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1878-66-6
4-chlorophenylacetic Acid

: 1596336-84-3
(4-aminopyridin-2-yl)-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)methanone

: 1596335-36-2
2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

Guidance literature:: With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 16h;

Reference yield:

: 175791-53-4
5-Iodopyrrolo<2,3-d>pyrimidine

: 1596335-36-2
2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

2.2: 3 h / -78 - 20 °C / Inert atmosphere

3.1: ammonium hydroxide; copper(ll) sulfate pentahydrate / 17 h / 140 °C / Sealed tube

4.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 16 h / 20 °C

With ammonium hydroxide; n-butyllithium; copper(ll) sulfate pentahydrate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 5-iodo-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

: 1596335-36-2
2-(4-chlorophenyl)-N-[2-(7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)pyridin-4-yl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; diethyl ether / 0.5 h / -78 °C / Inert atmosphere

1.2: 3 h / -78 - 20 °C / Inert atmosphere

2.1: ammonium hydroxide; copper(ll) sulfate pentahydrate / 17 h / 140 °C / Sealed tube

3.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / tetrahydrofuran; ethyl acetate / 16 h / 20 °C

With ammonium hydroxide; n-butyllithium; copper(ll) sulfate pentahydrate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In tetrahydrofuran; diethyl ether; hexane; ethyl acetate;