t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

Base Information

• Chemical Name: t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide
• CAS No.: 64699-01-0
• Molecular Formula: C₄₁H₆₀N₈O₉S
• Molecular Weight: 841.042

Synonyms:t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

Chemical Property of t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

Chemical Property:

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Technology Process of t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

There total 21 articles about t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

leucyl-methionine amide hydrochloride (2131-00-2) + N-t-Boc-Gln-Phe-Phe-Gly-OH (64699-00-9) → t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide (64699-01-0)

Guidance literature:

With 4-methyl-morpholine; hydrogenchloride; isobutyl chloroformate; In N,N-dimethyl-formamide; at -15 ℃;

DOI:10.1016/0223-5234(88)90006-2

Reference yield: 71.0%

H-Gly-Leu-Met-NH2 (4652-64-6) + Boc-Gln-Phe-Phe-OBzl-SO3Na (92278-82-5) → t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide (64699-01-0)

Guidance literature:

With 0.2 μmol α-chymotrypsine; In water; N,N-dimethyl-formamide; for 0.333333h; Ambient temperature; Carbonate buffer (0.2 mol/l; pH=10);

Reference yield:

Boc-Gln-OH (13726-85-7) + N-t-Boc-Phe-Phe-Gly-Leu-Met-NH2 (73148-99-9) → t-butyloxycarbonyl-glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide (64699-01-0)

Guidance literature:

N-t-Boc-Phe-Phe-Gly-Leu-Met-NH₂; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.166667h; Inert atmosphere;

Boc-Gln-OH; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1039/d1nj02751d

upstream raw materials:

H-Gly-Leu-Met-NH₂

Boc-Gln-Phe-Phe-OBzl-SO₃Na

leucyl-methionine amide hydrochloride

N-t-Boc-Gln-Phe-Phe-Gly-OH

Downstream raw materials:

glutamyl-phenylalanyl-phenylalanyl-glycyl-leucyl-methionine amide

(S)-2-Amino-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide); hydrochloride

(S)-2-((S)-2,5-Diamino-pentanoylamino)-pentanedioic acid 5-amide 1-({(S)-1-[(S)-1-({[(S)-1-((S)-1-carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-methyl}-carbamoyl)-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-amide)

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