(1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

Base Information

Chemical Name:(1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate
CAS No.:322407-41-0
Molecular Formula:C₃₉H₃₈NO₄PS
Molecular Weight:647.775
Hs Code.:

Synonyms:(1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

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Chemical Property of (1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

Chemical Property:

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Technology Process of (1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

There total 8 articles about (1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 931-15-7,931-16-8,6850-38-0,6982-39-4,33092-82-9,38898-70-3,74111-21-0,108267-20-5
(1S,2S)-trans-2-aminocyclohexanol

: 322407-41-0
(1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

2: 98 percent / K₂CO₃ / methanol / 1 h / Heating

3: 90 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

4: 90 percent / Et₃N / CH₂Cl₂ / 2.3 h / 0 °C

5: 96 percent / tetrahydrofuran / 5.5 h / 0 °C

6: 91 percent / 3 h / Heating

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(00)00340-2

Reference yield:

: 286-20-4
cyclohexane-1,2-epoxide

: 322407-41-0
(1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 8 steps

1.1: Me₃Al / CH₂Cl₂; hexane / 1 h / 0 °C

1.2: 39 percent / CH₂Cl₂ / 21 h / 0 - 20 °C

2.1: H₂ / 10 percent Pd/C / methanol / 72 h / 20 °C

3.1: 83 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

4.1: 98 percent / K₂CO₃ / methanol / 1 h / Heating

5.1: 90 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

6.1: 90 percent / Et₃N / CH₂Cl₂ / 2.3 h / 0 °C

7.1: 96 percent / tetrahydrofuran / 5.5 h / 0 °C

8.1: 91 percent / 3 h / Heating

With lithium aluminium tetrahydride; hydrogen; trimethylaluminum; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; hexane; dichloromethane;
DOI:10.1016/S0957-4166(00)00340-2

Reference yield:

: 98361-56-9
(1S,2S)-trans-2-[(R)-(α-methylbenzyl)amino]cyclohexanol

: 322407-41-0
(1S,2S)-trans-2-(N-benzenesulfonyl-N-benzyl)aminocyclohexyl (triphenylphosphoranylidene)acetate

Guidance literature:: Multi-step reaction with 7 steps

1: H₂ / 10 percent Pd/C / methanol / 72 h / 20 °C

2: 83 percent / Et₃N / CH₂Cl₂ / 3 h / 0 °C

3: 98 percent / K₂CO₃ / methanol / 1 h / Heating

4: 90 percent / LiAlH₄ / tetrahydrofuran / 3 h / Heating

5: 90 percent / Et₃N / CH₂Cl₂ / 2.3 h / 0 °C

6: 96 percent / tetrahydrofuran / 5.5 h / 0 °C

7: 91 percent / 3 h / Heating

With lithium aluminium tetrahydride; hydrogen; potassium carbonate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0957-4166(00)00340-2