(S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide

Base Information

• Chemical Name: (S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide
• CAS No.: 1417739-49-1
• Molecular Formula: C₁₅H₂₂F₃NO₃S
• Molecular Weight: 353.406

Synonyms:(S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide

Chemical Property of (S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide

Chemical Property:

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Technology Process of (S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide

There total 2 articles about (S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone (30724-22-2) + sodium ethanolate (141-52-6) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide (1417739-49-1) + (S)-N-((S)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide (1417739-90-2)

Guidance literature:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone; (S)-2-methylpropane-2-sulfinamide; With titanium(IV) isopropylate; In hexane; toluene; at 20 ℃; for 12h; Inert atmosphere;

sodium ethanolate; In ethanol; hexane; at -40 ℃; diastereoselective reaction; Inert atmosphere;

DOI:10.1002/cjoc.201300344

Reference yield:

titanium(IV) tetraethanolate + 2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone (30724-22-2) + (S)-2-methylpropane-2-sulfinamide (343338-28-3) → (S)-N-((R)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide (1417739-49-1) + (S)-N-((S)-1-ethoxy-2,2,2-trifluoro-1-(3-methoxyphenyl)ethyl)-tert-butylsulfinamide (1417739-90-2)

Guidance literature:

In hexane; at 20 ℃; Optical yield = 14 %de;

DOI:10.1002/ejoc.201300890

upstream raw materials:

2,2,2-trifluoro-1-(3-methoxyphenyl)ethanone

sodium ethanolate

(S)-2-methylpropane-2-sulfinamide

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