N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline

Base Information

• Chemical Name: N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline
• CAS No.: 96667-93-5
• Molecular Formula: C₂₄H₂₅N₃
• Molecular Weight: 355.483
• Mol file: 96667-93-5.mol

Synonyms:N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline

Chemical Property of N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline

There total 5 articles about N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

3-[4-(dimethylamino)phenyl]-1-(4-methylphenyl)prop-2-en-1-one (19132-98-0) + phenylhydrazine hydrochloride (59-88-1) → N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline (96667-93-5)

Guidance literature:

In ethanol;

DOI:10.1016/j.bmcl.2005.08.040

Reference yield: 72.0%

3-(4-dimethylaminophenyl)-1-(p-tolyl)propan-1-one + phenylhydrazine (100-63-0) → N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline (96667-93-5)

Guidance literature:

With cerium(III) chloride heptahydrate; for 5h; Reflux;

DOI:10.1007/s12039-017-1327-x

Reference yield:

para-methylacetophenone (122-00-9) → N,N-dimethyl-4-(2-phenyl-5-p-tolyl-3,4-dihydro-2H-pyrazol-3-yl)-aniline (96667-93-5)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol / 20 °C

2: 78 percent / ethanol

With potassium hydroxide; In ethanol; 1: Claisen-Schmidt condensation;

DOI:10.1016/j.bmcl.2005.08.040

upstream raw materials:

3-[4-(dimethylamino)phenyl]-1-(4-methylphenyl)prop-2-en-1-one

phenylhydrazine hydrochloride

para-methylacetophenone

4-dimethylamino-benzaldehyde