(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

Base Information

Chemical Name:(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride
CAS No.:1428580-92-0
Molecular Formula:C₁₇H₂₅NO₂*ClH
Molecular Weight:311.852
Hs Code.:

Synonyms:(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

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Chemical Property of (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

Chemical Property:

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Technology Process of (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

There total 5 articles about (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]oct-3-en-3-yl)methanol citrate

: 1428580-92-0
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

Guidance literature:: (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]oct-3-en-3-yl)methanol citrate; With sodium hydroxide; In water; Inert atmosphere;

With platinum on carbon; hydrogen; In tetrahydrofuran; water; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; Inert atmosphere;
DOI:10.1021/op3002933

Reference yield:

: 8-(2-(benzyloxy)ethyl)-8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]

: 1428580-92-0
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

Guidance literature:: 8-(2-(benzyloxy)ethyl)-8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]; With diisobutylaluminium hydride; In 2-methyltetrahydrofuran; toluene; tert-butyl alcohol; at 10 - 60 ℃; for 4.5h; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; toluene; at 10 - 60 ℃; for 4.5h; Inert atmosphere;
DOI:10.1021/op3002933

Reference yield:

: 38336-04-8
O-benzylethanolamine

: 1428580-92-0
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 0 - 80 °C / Inert atmosphere

1.2: 5 - 45 °C / pH 4.6 - 5.3

2.1: potassium tert-butylate; trimethylsulfoxonium iodide / tert-butyl alcohol; 2-methyltetrahydrofuran / 16 h / 75 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene; tert-butyl alcohol; 2-methyltetrahydrofuran / 4.5 h / 10 - 60 °C / Inert atmosphere

3.2: 4.5 h / 10 - 60 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; trimethylsulfoxonium iodide; diisobutylaluminium hydride; In 2-methyltetrahydrofuran; water; toluene; tert-butyl alcohol; 2.1: |Corey-Tschaikosky Epoxidation;
DOI:10.1021/op3002933