(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

Base Information

Chemical Name:(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate
CAS No.:1428580-94-2
Molecular Formula:C₁₈H₂₇NO₄S
Molecular Weight:353.483
Hs Code.:

Synonyms:(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

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Chemical Property of (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

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Technology Process of (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

There total 6 articles about (8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1428580-92-0
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methanol hydrochloride

: 124-63-0
methanesulfonyl chloride

: 1428580-94-2
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/op3002933

Reference yield:

: 38336-04-8
O-benzylethanolamine

: 1428580-94-2
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / water / 0 - 80 °C / Inert atmosphere

1.2: 5 - 45 °C / pH 4.6 - 5.3

2.1: potassium tert-butylate; trimethylsulfoxonium iodide / tert-butyl alcohol; 2-methyltetrahydrofuran / 16 h / 75 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene; tert-butyl alcohol; 2-methyltetrahydrofuran / 4.5 h / 10 - 60 °C / Inert atmosphere

3.2: 4.5 h / 10 - 60 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With hydrogenchloride; potassium tert-butylate; trimethylsulfoxonium iodide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; water; toluene; tert-butyl alcohol; 2.1: |Corey-Tschaikosky Epoxidation;
DOI:10.1021/op3002933

Reference yield:

: 8-(2-(benzyloxy)ethyl)-8-azaspiro[bicyclo[3.2.1]octane-3,2'-oxirane]

: 1428580-94-2
(8-(2-(benzyloxy)ethyl)-8-azabicyclo[3.2.1]octan-3-yl)methyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisobutylaluminium hydride / toluene; tert-butyl alcohol; 2-methyltetrahydrofuran / 4.5 h / 10 - 60 °C / Inert atmosphere

1.2: 4.5 h / 10 - 60 °C / Inert atmosphere

2.1: triethylamine / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

With diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; 2-methyltetrahydrofuran; toluene; tert-butyl alcohol;
DOI:10.1021/op3002933