3,5-bis(4-methoxyphenyl)-1H-pyrazole

Base Information

• Chemical Name: 3,5-bis(4-methoxyphenyl)-1H-pyrazole
• CAS No.: 75059-30-2
• Molecular Formula: C₁₇H₁₆N₂O₂
• Molecular Weight: 280.326
• European Community (EC) Number: 869-671-2
• Nikkaji Number: J2.575.733E
• ChEMBL ID: CHEMBL1340776
• Mol file: 75059-30-2.mol

Synonyms:3,5-bis(4-methoxyphenyl)-1H-pyrazole;75059-30-2;SMR000039532;MLS000037760;SCHEMBL1181434;CHEMBL1340776;HRDCRGDKFGHPHP-UHFFFAOYSA-N;HMS2381F15;BBL040105;MFCD01877980;STK349859;AKOS000311116;CS-0240752;FT-0719457;EN300-229900

Chemical Property of 3,5-bis(4-methoxyphenyl)-1H-pyrazole

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 280.121177757
• Heavy Atom Count: 21
• Complexity: 310

Purity/Quality:

99% ^*data from raw suppliers

3,5-Bis(4-methoxyphenyl)-1H-pyrazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=CC(=NN2)C3=CC=C(C=C3)OC

Technology Process of 3,5-bis(4-methoxyphenyl)-1H-pyrazole

There total 12 articles about 3,5-bis(4-methoxyphenyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dimethoxychalcone (2373-89-9) → 3,5-bis(4-methoxiphenyl)-1H-pyrazole (75059-30-2)

Guidance literature:

With sulfur; hydrazine hydrate; In ethanol; at 150 ℃; for 2h; Microwave irradiation;

DOI:10.1002/chem.201502995

Reference yield: 94.0%

(E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one (41564-67-4) → 3,5-bis(4-methoxiphenyl)-1H-pyrazole (75059-30-2)

Guidance literature:

With sulfur; hydrazine hydrate; In ethanol; at 150 ℃; for 2h; microwave irradiation;

DOI:10.1002/jhet.5570450231

Reference yield: 91.0%

1,3-bis(4'-methoxyphenyl)propane-1,3-dione (18362-51-1) → 3,5-bis(4-methoxiphenyl)-1H-pyrazole (75059-30-2)

Guidance literature:

With hydrazine hydrate; In tetrahydrofuran; N,N-dimethyl-formamide; for 18h; Reflux;

upstream raw materials:

1,3-bis(4'-methoxyphenyl)propane-1,3-dione

ethyl 4-methoxybenzoate

(E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one

(2RS,3SR)-2,3-epoxy-1-(4-methoxyphenyl)-3-(4-methoxyphenyl)propan-1-one

Downstream raw materials:

[Au(3,5-bis(4'-methoxyphenyl)pyrazolate)]3

1,2,5-tri-(4-anisyl)-1H-pyrazole