4,4'-Dimethoxychalcone

Base Information

• Chemical Name: 4,4'-Dimethoxychalcone
• CAS No.: 2373-89-9
• Molecular Formula: C17H16 O3
• Molecular Weight: 268.312
• Hs Code.: 2914509090
• European Community (EC) Number: 666-868-3
• NSC Number: 87339
• UNII: 8KJ379G3P2
• DSSTox Substance ID: DTXSID001311791
• Nikkaji Number: J150.792C,J648.374G
• Wikidata: Q76305845
• Pharos Ligand ID: PAYF1TMZK3KX
• Metabolomics Workbench ID: 73708
• ChEMBL ID: CHEMBL138314
• Mol file: 2373-89-9.mol

Synonyms:4,4'-Dimethoxychalcone;2373-89-9;(E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one;1,3-bis(4-methoxyphenyl)prop-2-en-1-one;(E)-4,4'-Dimethoxychalcone;41564-67-4;trans-4,4'-Dimethoxychalcone;(2E)-1,3-bis(4-methoxyphenyl)prop-2-en-1-one;8KJ379G3P2;1,3-Bis(4-methoxyphenyl)propenone;NSC-87339;2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-, (2E)-;UNII-8KJ379G3P2;2-Propen-1-one, 1,3-bis(4-methoxyphenyl)-;NSC 87339;AI3-25492;(E)-beta-(4-Methoxyphenyl)-4'-methoxyacrylophenone;NSC87339;4,4/'-Dimethoxychalcone;SCHEMBL978242;CHEMBL138314;HDXVSZWKIHQDES-LFYBBSHMSA-N;DTXSID001311791;BBL000677;MFCD00025815;STK366699;AKOS000991654;AKOS040759299;FS-4109;NCGC00342031-01;AC-34206;PD157603;1,3-bis(4-methoxyphenyl)-2-propen-1-one;HY-136064;CS-0119411;E85264;1,3-Bis-(4-methoxy-phenyl)-prop-2-en-1-one;AB01333999-02;(2E)-1,3-Bis(4-methoxyphenyl)-2-propen-1-one;A816874;AE-641/00371054

Chemical Property of 4,4'-Dimethoxychalcone

Chemical Property:

• Melting Point: 101oC
• Boiling Point: 444.6±45.0 °C(Predicted)
• Flash Point: 214.6oC
• PSA: 35.53000
• Density: 1.128±0.06 g/cm3(Predicted)
• LogP: 3.59990
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 268.109944368
• Heavy Atom Count: 20
• Complexity: 321

Purity/Quality:

99% ^*data from raw suppliers

4,4'-DIMETHOXYCHALCONE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): N
• Hazard Codes: N

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C=CC(=O)C2=CC=C(C=C2)OC
• Isomeric SMILES: COC1=CC=C(C=C1)/C=C/C(=O)C2=CC=C(C=C2)OC

Technology Process of 4,4'-Dimethoxychalcone

There total 21 articles about 4,4'-Dimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 4,4'-dimethoxychalcone (2373-89-9)

Guidance literature:

With boron tribromide; In dichloromethane; at 55 ℃; for 0.5h; Microwave irradiation;

Reference yield: 98.0%

4-methoxy-benzaldehyde (123-11-5) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 4,4'-dimethoxychalcone (2373-89-9)

Guidance literature:

With sodium ethanolate; at 20 ℃; for 2h;

Reference yield: 96.0%

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + 4-methoxy-benzaldehyde (123-11-5) + malononitrile (109-77-3) → 4,4'-dimethoxychalcone (2373-89-9)

Guidance literature:

With ZnTiO₃ nanopowder; In water; at 20 ℃; for 0.75h;

DOI:10.1039/c2gc16641k

upstream raw materials:

ethanol

4-methoxy-benzaldehyde

1-(4-methoxyphenyl)ethanone

2,3-dibromo-1,3-bis(4-methoxyphenyl)propan-1-one

Downstream raw materials:

2,4-bis(4-methoxyphenyl)-4-oxobutanenitrile

2-cyano-3,5-bis-(4-methoxy-phenyl)-5-oxo-valeric acid

1,3-bis(4-methoxyphenyl)propane

2,3-dibromo-1,3-bis(4-methoxyphenyl)propan-1-one

Refernces

• 1、 Farahi, Mahnaz,Karami, Bahador,Keshavarz, Raziyeh,Nia, Forough Motamedi. "Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst". . p. 407 - 414. Retrieved 2021/09/07.
• 2、 Y?lmaz, Halil,Sevin?, G?khan,Hayval?, Mustafa. "3, 3,5 and 2,6 Expanded Aza-BODIPYs Via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling Reactions: Synthesis and Photophysical Properties". . p. 151 - 164. Retrieved 2020/11/12.