tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate
CAS No.:1429181-92-9
Molecular Formula:C₃₀H₄₄N₆O₄
Molecular Weight:552.717
Hs Code.:

Synonyms:tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

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Technology Process of tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

There total 5 articles about tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

: 1429182-96-6
4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzaldehyde

: 674792-07-5
2,2-dimethyl-piperazine-1-carboxylic acid tert-butyl ester

: 1429181-92-9
tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

Guidance literature:: With 5-ethyl-2-methylpyridine borane complex; water; acetic acid; In methanol; at 50 ℃; for 4h;

Reference yield:

: 1429182-99-9
(S)-3-(2-((S)-1-(4-(hydroxymethyl)phenyl)ethylamino)pyrimidin-4-yl)-4-isopropyloxazolidin-2-one

: 1429181-92-9
tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / dichloromethane / 0.5 h / 20 °C

2: acetic acid; 5-ethyl-2-methylpyridine borane complex; water / methanol / 4 h / 50 °C

With manganese(IV) oxide; 5-ethyl-2-methylpyridine borane complex; water; acetic acid; In methanol; dichloromethane;

Reference yield:

: 1429181-06-5
(S)-3-(2-fluoropyrimidin-4-yl)-4-isopropyloxazolidin-2-one

: 1429181-92-9
tert-butyl 4-(4-((S)-1-(4-((S)-4-isopropyl-2-oxooxazolidin-3-yl)pyrimidin-2-ylamino)ethyl)benzyl)-2,2-dimethylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 2.25 h / 110 °C

2: manganese(IV) oxide / dichloromethane / 0.5 h / 20 °C

3: 5-ethyl-2-methylpyridine borane complex; acetic acid / methanol; water / 6 h / 20 - 50 °C

With manganese(IV) oxide; 5-ethyl-2-methylpyridine borane complex; acetic acid; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; water; dimethyl sulfoxide;