(R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

Base Information

Chemical Name:(R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one
CAS No.:865107-61-5
Molecular Formula:C₃₄H₄₇NO₇
Molecular Weight:581.75
Hs Code.:

Synonyms:(R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

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Chemical Property of (R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

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Technology Process of (R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

There total 7 articles about (R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 865107-57-9
(2S,4R)-5-(4-methoxybenzyloxy)-2,4-dimethylpentyl acetate

: 865107-61-5
(R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 84 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

2.1: 83 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 12 h / 20 °C

3.1: TiCl₄; i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / -5 °C

3.2: 74 percent / CH₂Cl₂; toluene / 12.5 h / -78 - -50 °C

4.1: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

5.1: 3.80 g / CSA / 6 h / 20 °C

With pyridine; lithium aluminium tetrahydride; zinc(II) tetrahydroborate; camphor-10-sulfonic acid; titanium tetrachloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; toluene; 2.1: Dess-Martin oxidation;
DOI:10.1021/jo050924a

Reference yield:

: 865107-60-4
(R)-3-((2R,4R,5S,6S,8R)-9-(4-methoxybenzyloxy)-5-hydroxy-2,4,6,8-tetramethyl-3-oxononanoyl)-4-benzyloxazolidin-2-one

: 865107-61-5
(R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

2: 3.80 g / CSA / 6 h / 20 °C

With zinc(II) tetrahydroborate; camphor-10-sulfonic acid; In diethyl ether; dichloromethane;
DOI:10.1021/jo050924a

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 865107-61-5
(R)-3-((R)-2-((4S,5R,6S)-6-((2S,4R)-5-(4-methoxybenzyloxy)-4-methylpentan-2-yl)-2,2,5-trimethyl-1,3-dioxan-4-yl)propanoyl)-4-benzyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 93 percent / CSA / diethyl ether / 24 h / 20 °C

2.1: 84 percent / LiAlH₄ / diethyl ether / 0 - 20 °C

3.1: 83 percent / Dess-Martin periodinane; pyridine / CH₂Cl₂ / 12 h / 20 °C

4.1: TiCl₄; i-Pr₂NEt / CH₂Cl₂; toluene / 1 h / -5 °C

4.2: 74 percent / CH₂Cl₂; toluene / 12.5 h / -78 - -50 °C

5.1: Zn(BH₄)2 / CH₂Cl₂; diethyl ether / 0.5 h / -78 °C

6.1: 3.80 g / CSA / 6 h / 20 °C

With pyridine; lithium aluminium tetrahydride; zinc(II) tetrahydroborate; camphor-10-sulfonic acid; titanium tetrachloride; Dess-Martin periodane; N-ethyl-N,N-diisopropylamine; In diethyl ether; dichloromethane; toluene; 3.1: Dess-Martin oxidation;
DOI:10.1021/jo050924a