(1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide

Base Information

• Chemical Name: (1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide
• CAS No.: 1352924-74-3
• Molecular Formula: C₃₁H₄₂N₆O₅
• Molecular Weight: 578.712

Synonyms:(1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide

Chemical Property of (1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide

There total 1 articles about (1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + 1-[(S)-3-azido-2-isocyanopropyl]benzene (1223635-87-7) + 4-methoxy-benzylamine (2393-23-9) + acetone (67-64-1) → (1-tert-butoxycarbonyl-L-prolyl)-N1-[(2S)-1-azido-3-phenyl-prop-2-yl]-N2-(4-methoxybenzyl)-2-methylalanineamide (1352924-74-3)

Guidance literature:

In methanol; at 20 ℃; for 24h;

DOI:10.1007/s11172-011-0369-3

Reference yield: 46.0%

N-(3-oxo-20(29)-lupen-28-oyl)-4-ethynylaniline (1185845-52-6) + (1-tert-butoxycarbonyl-L-prolyl)-N1-[(2S)-1-azido-3-phenyl-prop-2-yl]-N2-(4-methoxybenzyl)-2-methylalanineamide (1352924-74-3) → (1-tert-butoxycarbonyl-L-prolyl)-N1-((2S)-1-{4-[4-(3,28-dioxolup-20(29)-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N2-(4-methoxybenzyl)-2-methylalanineamide (1392483-51-0)

Guidance literature:

With copper(l) chloride; In butan-1-ol; at 110 - 115 ℃;

DOI:10.1007/s11172-011-0369-3

Reference yield:

diethyl 1-(benzyloxycarbonylamino)-1-trifluoromethylprop-2-yne-1-ylphosphonate (1228473-29-7) + (1-tert-butoxycarbonyl-L-prolyl)-N1-[(2S)-1-azido-3-phenyl-prop-2-yl]-N2-(4-methoxybenzyl)-2-methylalanineamide (1352924-74-3) → 1-(tert-butoxycarbonyl)prolyl-N1-(1-benzyl-2-{4-[1-{[(benzyloxy)carbonyl]amino}-1-(diethoxyphosphoryl)-2,2,2-trifluoroethyl]-1H-1,2,3-triazol-1-yl}ethyl)-N2-(4-methoxybenzyl)-2-methylalaninamide + 1-(tert-butoxycarbonyl)prolyl-N1-(1-benzyl-2-{4-[1-{[(benzyloxy)carbonyl]amino}-1-(diethoxyphosphoryl)-2,2,2-trifluoroethyl]-1H-1,2,3-triazol-1-yl}ethyl)-N2-(4-methoxybenzyl)-2-methylalaninamide

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 90 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2011.11.037

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

1-[(S)-3-azido-2-isocyanopropyl]benzene

4-methoxy-benzylamine

acetone

Downstream raw materials:

(1-tert-butoxycarbonyl-L-prolyl)-N¹-((2S)-1-{4-[4-(3,28-dioxolup-20⁽²⁹⁾-en-28-ylamino)phenyl]-1H-1,2,3-triazol-1-yl}3-phenylprop-2-yl)-N²-(4-methoxybenzyl)-2-methylalanineamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1352924-74-3 (1-tert-butoxycarbonyl-L-prolyl)-N¹-[(2S)-1-azido-3-phenyl-prop-2-yl]-N²-(4-methoxybenzyl)-2-methylalanineamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send