1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

Base Information

Chemical Name:1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene
CAS No.:216978-21-1
Molecular Formula:C₁₈H₂₅ClO₂
Molecular Weight:308.848
Hs Code.:

Synonyms:1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

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Chemical Property of 1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

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Technology Process of 1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

There total 16 articles about 1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1826-67-1
vinyl magnesium bromide

: 189444-01-7
5-Formyl-1-(6-chloro-1-oxohex-2-ynyl)-2,6,6-trimethylcyclohex-1-ene

: 216978-21-1
1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

Guidance literature:: In tetrahydrofuran; at -78 ℃;

Reference yield: 98.0%

: 3536-96-7
vinylmagnesium chloride

: 189444-01-7
5-Formyl-1-(6-chloro-1-oxohex-2-ynyl)-2,6,6-trimethylcyclohex-1-ene

: 216978-21-1
1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 2h;
DOI:10.1039/a805268i

Reference yield:

: 189443-99-0
1-Formyl-5-(1,3-dioxolan-2-yl)-2,6,6-trimethylcyclohex-1-ene

: 216978-21-1
1-(6-Chloro-1-oxohex-2-ynyl)-5-(1-hydroxyprop-2-enyl)-2,6,6-trimethylcyclohex-1-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / n-BuLi / hexane; tetrahydrofuran / 1.) 0 deg C, 15 min, 2.) -78 deg C, 30 min

2: 98 percent / tetra(n-propyl)ammonium perruthenate, NMO, 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / Ambient temperature

3: 98 percent / CSA, H₂O / tetrahydrofuran / 14 h / Heating

4: 98 percent / tetrahydrofuran / 2 h / -78 °C

With n-butyllithium; N-methyl-2-indolinone; tetrapropylammonium perruthennate; 4 A molecular sieve; camphor-10-sulfonic acid; water; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1039/a805268i