trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane

Base Information

• Chemical Name: trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane
• CAS No.: 908274-93-1
• Molecular Formula: C₁₆H₃₀O₃Si
• Molecular Weight: 298.498
• Mol file: 908274-93-1.mol

Synonyms:trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane

Chemical Property of trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane

There total 2 articles about trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

chloro-trimethyl-silane (75-77-4) + 1-cyclohexene-1-carboxaldehyde (1192-88-7) + 2-(2-methyl-1,3-dioxolan-2-yl)ethylmagnesium bromide → trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane (908274-93-1)

Guidance literature:

With copper(I) bromide dimethylsulfide complex; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at -78 ℃; for 6h;

DOI:10.1021/ol061096q

Reference yield:

2-(2-bromoethyl)-2-methyl-1,3-dioxolane (37865-96-6) → trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane (908274-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: Mg / tetrahydrofuran / 1 h / 20 °C

2: 80 percent / CuBr*Me₂S / hexamethylphosphoric acid triamide; tetrahydrofuran / 6 h / -78 °C

With copper(I) bromide dimethylsulfide complex; magnesium; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1021/ol061096q

Reference yield:

trimethyl-(2-(2-(2-methyl-[1,3]dioxolan-2-yl)-ethyl)-cyclohexylidene-methoxy)-silane (908274-93-1) → (1R,2S)-2-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-cyclohexanecarbaldehyde + (1R,2R)-2-[2-(2-Methyl-[1,3]dioxolan-2-yl)-ethyl]-cyclohexanecarbaldehyde

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 5h; Title compound not separated from byproducts;

DOI:10.1021/ol061096q

upstream raw materials:

chloro-trimethyl-silane

1-cyclohexene-1-carboxaldehyde

2-(2-bromoethyl)-2-methyl-1,3-dioxolane