morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

Base Information

Chemical Name:morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone
CAS No.:1548118-12-2
Molecular Formula:C₂₀H₂₉N₃O₂Si
Molecular Weight:371.555
Hs Code.:

Synonyms:morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

Chemical Property:

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Technology Process of morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

There total 5 articles about morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1548115-92-9
(4-(4-iodophenyl)piperazin-1-yl)(morpholino)methanone

: 1066-54-2
trimethylsilylacetylene

: 1548118-12-2
morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 15h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.050

Reference yield:

: 163587-60-8
4-(4-morpholinylcarbonyl)-1-piperazinecarboxylic acid 1,1-dimethylethyl ester

: 1548118-12-2
morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / toluene / 16 h / Inert atmosphere

3: copper(l) iodide; sodium iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 48 h / 110 °C / Inert atmosphere

4: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium diacetate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; sodium iodide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; 4: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2013.12.050

Reference yield:

: 98834-08-3
piperazinocarboxylic acid morpholide

: 1548118-12-2
morpholino(4-(4-((trimethylsilyl)ethynyl)phenyl)piperazin-1-yl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / toluene / 16 h / Inert atmosphere

2: copper(l) iodide; sodium iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / 1,4-dioxane / 48 h / 110 °C / Inert atmosphere

3: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 15 h / 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium diacetate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium iodide; In tetrahydrofuran; 1,4-dioxane; toluene; 3: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmc.2013.12.050