methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

Base Information

Chemical Name:methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate
CAS No.:1367874-55-2
Molecular Formula:C₂₃H₂₆N₄O₄
Molecular Weight:422.484
Hs Code.:

Synonyms:methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

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Chemical Property of methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

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Technology Process of methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

There total 6 articles about methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1367874-54-1
3-iodo-1-(4-methoxybenzyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-amine

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1367874-55-2
methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

Guidance literature:: With tetra-(n-butyl)ammonium iodide; triethylamine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 20 - 70 ℃;

Reference yield:

: 134031-24-6
2,4-dichloro-3-pyridine Carboxaldehyde

: 1367874-55-2
methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

2: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

3: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

4: butan-1-ol / 1 h / 20 - 180 °C / Microwave irradiation

5: tetra-(n-butyl)ammonium iodide; triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 20 - 70 °C

With iodine; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; triethylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 26452-80-2
2,4-dichloropyridine

: 1367874-55-2
methyl(2E)-3[1-(4-methoxybenzyl)-4(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[4,3-c]pyridin-3-yl]prop-2-enoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3.5 h / -78 - 0 °C

1.2: 1.5 h / -78 °C

2.1: hydrazine hydrate / 1,2-dimethoxyethane / 20 - 75 °C

3.1: iodine; potassium hydroxide / 1,4-dioxane / 4 h / 75 °C

4.1: potassium hydroxide / N,N-dimethyl-formamide / 2.5 h / 20 °C

5.1: butan-1-ol / 1 h / 20 - 180 °C / Microwave irradiation

6.1: tetra-(n-butyl)ammonium iodide; triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 20 - 70 °C

With n-butyllithium; iodine; tetra-(n-butyl)ammonium iodide; hydrazine hydrate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; butan-1-ol;