(S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol

Base Information

• Chemical Name: (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol
• CAS No.: 137604-28-5
• Molecular Formula: C₂₂H₂₆N₂O
• Molecular Weight: 334.461
• Mol file: 137604-28-5.mol

Synonyms:(S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol

Chemical Property of (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol

There total 4 articles about (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + (S)-4-amino-3-(N,N-dibenzylamino)-1-butanol (137604-26-3) → (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol (137604-28-5)

Guidance literature:

With sodium acetate; In acetic acid; at 70 ℃; for 2h;

DOI:10.3987/COM-90-5578

Reference yield:

(S)-3-N,N-dibenzylamino-4-mesyloxybutanenitrile (131270-10-5) → (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol (137604-28-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / NaN₃ / dimethylformamide / 1 h / 55 °C

2: 86 percent / conc. aq. HCl / 5 h / 80 °C

3: 85 percent / BH₃*THF / tetrahydrofuran / 4 h / Heating

4: 90 percent / NaOAc*3H₂O / acetic acid / 2 h / 70 °C

With hydrogenchloride; sodium azide; borane-THF; sodium acetate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;

DOI:10.3987/COM-90-5578

Reference yield:

(S)-4-azido-3-N,N-dibenzylaminobutanoic acid (137604-24-1) → (S)-3-N,N-dibenzylamino-4-N-pyrrolylbutanol (137604-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / BH₃*THF / tetrahydrofuran / 4 h / Heating

2: 90 percent / NaOAc*3H₂O / acetic acid / 2 h / 70 °C

With borane-THF; sodium acetate; In tetrahydrofuran; acetic acid;

DOI:10.3987/COM-90-5578

upstream raw materials:

cis,trans-2,5-dimethoxytetrahydrofuran

(S)-4-amino-3-(N,N-dibenzylamino)-1-butanol

(S)-3-N,N-dibenzylamino-4-mesyloxybutanenitrile

(S)-4-azido-3-N,N-dibenzylaminobutanenitrile

Downstream raw materials:

(S)-6-N,N-dibenzylamino-5,6,7,8-tetrahydroindolizine