(4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

Base Information

Chemical Name:(4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate
CAS No.:1202488-07-0
Molecular Formula:C₃₅H₃₇N₃O₆
Molecular Weight:595.695
Hs Code.:

Synonyms:(4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

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Chemical Property of (4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

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Technology Process of (4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

There total 7 articles about (4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202488-04-7
(4R,6R,7S)-(4-(2-oxo-4-([1,2,4]triazol-1-yl)-pyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]hept-7-yl) isobutyrate

: 1202488-07-0
(4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

Guidance literature:: With ammonium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1021/jm101050a

Reference yield:

: 1202487-81-7
1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

: 1202488-07-0
(4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 20 °C / Cooling with cold water

2: triethylamine; trichlorophosphate / dichloromethane / 20 - 25 °C

3: ammonium hydroxide / tetrahydrofuran

With pyridine; ammonium hydroxide; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1202488-01-4
(4R,6R,7S)-(4-(2,4-dioxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyldiphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

: 1202488-07-0
(4R,6R,7S)-(4-(4-amino-2-oxopyrimidin-1(2H)-yl)-6-[(4-methoxyphenyl)(diphenyl)methoxymethyl]-5-oxaspiro[2.4]-hept-7-yl) isobutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; trichlorophosphate / dichloromethane / 20 - 25 °C

2: ammonium hydroxide / tetrahydrofuran

With ammonium hydroxide; triethylamine; trichlorophosphate; In tetrahydrofuran; dichloromethane;