1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

Base Information

Chemical Name:1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione
CAS No.:1202487-81-7
Molecular Formula:C₃₁H₃₀N₂O₆
Molecular Weight:526.589
Hs Code.:

Synonyms:1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

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Chemical Property of 1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

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Technology Process of 1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

There total 4 articles about 1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140902-02-9
1-((4R,6R,7S)-7-hydroxy-6-hydroxymethyl-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

: 14470-28-1
mono-4-methoxytrityl chloride

: 1202487-81-7
1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

Guidance literature:: With pyridine; at 0 - 20 ℃; for 12h;
DOI:10.1021/jm101050a

Reference yield:

: 1202651-75-9
3-benzoyl-1-((6aR,8R,9aS)-2,2,4,4-tetraisopropyl-4',5',6,6a,8,9a-hexahydrospiro[furo[3,2-f][1,3,5,2,4]-trioxadisilocine-9,3'-pyrazole]-8-yl)pyrimidine-2,4(1H,3H)-dione

: 1202487-81-7
1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzophenone / acetonitrile; benzene / 20 °C / Inert atmosphere; Irradiation with halogen lamp

2.1: ammonia / methanol; dichloromethane / 1 h

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

3.2: Dowex 50 Wx₄ / 0.75 h

4.1: pyridine / 20 °C / Cooling with ice

With pyridine; benzophenone; tetrabutyl ammonium fluoride; ammonia; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; benzene;

Reference yield:

: 140902-00-7
1-((6a′R,8′R,9a′S)-2′,2′,4′,4′-tetraisopropyltetrahydrospiro[cyclopropane-1,9′-furo[3,2-f ][1,3,5,2,4]trioxadisilocin]-8′-yl)pyrimidine-2,4(1H,3H)-dione

: 1202487-81-7
1-((4R,6R,7S)-7-hydroxy-6-((4-methoxyphenyl)(diphenyl)methoxymethyl)-5-oxaspiro[2.4]hept-4-yl)-1H-pyrimidin-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C

1.2: Dowex 50 Wx₄ / 0.75 h

2.1: pyridine / 20 °C / Cooling with ice

With pyridine; tetrabutyl ammonium fluoride; In tetrahydrofuran;