5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

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Chemical Name:5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide
CAS No.:1413061-00-3
Molecular Formula:C₂₅H₂₆N₄O₃
Molecular Weight:430.506
Hs Code.:

Synonyms:5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

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Chemical Property of 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

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Technology Process of 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

There total 8 articles about 5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1413064-29-5
5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid

: 1413061-00-3
5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: With ammonia; triethylamine; HATU; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

: 69321-60-4
2,6-dibromotoluene

: 1413061-00-3
5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 20 h / Reflux

2: N,N-dimethyl-formamide / 6 h / 105 °C

3: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

4: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

5: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C

6: ammonia / methanol / 48 h / 20 °C

7: sodium hydroxide; water / 1,4-dioxane / 16 h / 20 °C

8: triethylamine; ammonia; HATU / tetrahydrofuran / 16 h / 20 °C

With N-Bromosuccinimide; ammonia; water; potassium acetate; potassium carbonate; caesium carbonate; triethylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; N,N-dimethylethylenediamine; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 93701-32-7
2,6-dibromobenzyl bromide

: 1413061-00-3
5-[3-(6-tert-butyl-1-oxo-1H-phthalazin-2-yl)-2-hydroxymethyl-phenyl]-1-methyl-1H-pyrrole-2-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: N,N-dimethyl-formamide / 6 h / 105 °C

2: caesium carbonate / copper(l) iodide; N,N-dimethylethylenediamine / N,N-dimethyl-formamide / 4 h / 150 °C / Inert atmosphere

3: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 80 °C / Inert atmosphere

4: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 3 h / 100 °C

5: ammonia / methanol / 48 h / 20 °C

6: sodium hydroxide; water / 1,4-dioxane / 16 h / 20 °C

7: triethylamine; ammonia; HATU / tetrahydrofuran / 16 h / 20 °C

With ammonia; water; potassium acetate; potassium carbonate; caesium carbonate; triethylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; N,N-dimethylethylenediamine; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;