N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

Base Information

Chemical Name:N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide
CAS No.:1262663-64-8
Molecular Formula:C₂₀H₁₀Br₂F₈N₂O₂
Molecular Weight:622.107
Hs Code.:

Synonyms:N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

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Chemical Property of N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

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Technology Process of N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

There total 4 articles about N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262665-44-0
2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

: 72369-87-0
quinoline-6-carbonyl chloride

: 1262663-64-8
N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

Guidance literature:: 2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline; quinoline-6-carbonyl chloride; With pyridine; In dichloromethane; for 5h; Reflux;

With lithium hydroxide; In tetrahydrofuran; water; at 18 - 30 ℃; for 2h;

Reference yield:

: 10349-57-2
Quinoline-6-carboxylic acid

: 1262663-64-8
N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2.33 h / 18 - 30 °C / Reflux

2.1: pyridine / dichloromethane / 5 h / Reflux

2.2: 2 h / 18 - 30 °C

With pyridine; oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane;

Reference yield:

: 22236-04-0
2-(difluoromethoxy)aniline

: 1262663-64-8
N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; sodium dithionite / water; tert-butyl methyl ether / 48 h / 18 - 30 °C

2.1: N-Bromosuccinimide / acetic acid / 3 h / 70 °C

3.1: pyridine / dichloromethane / 5 h / Reflux

3.2: 2 h / 18 - 30 °C

With pyridine; N-Bromosuccinimide; sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In dichloromethane; tert-butyl methyl ether; water; acetic acid;