2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

Base Information

Chemical Name:2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline
CAS No.:1262665-44-0
Molecular Formula:C₁₀H₅Br₂F₈NO
Molecular Weight:466.951
Hs Code.:

Synonyms:2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

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Chemical Property of 2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

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Technology Process of 2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

There total 2 articles about 2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1262665-43-9
4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

: 1262665-44-0
2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

Guidance literature:: With N-Bromosuccinimide; In acetic acid; at 70 ℃; for 3h;

Reference yield:

: 22236-04-0
2-(difluoromethoxy)aniline

: 1262665-44-0
2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; sodium dithionite / water; tert-butyl methyl ether / 48 h / 18 - 30 °C

2: N-Bromosuccinimide / acetic acid / 3 h / 70 °C

With N-Bromosuccinimide; sodium dithionite; tetra(n-butyl)ammonium hydrogensulfate; sodium hydrogencarbonate; In tert-butyl methyl ether; water; acetic acid;

Reference yield:

: 1262665-44-0
2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline

: 72369-87-0
quinoline-6-carbonyl chloride

: 1262663-64-8
N-[2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)phenyl]quinoline-6-carboxamide

Guidance literature:: 2-bromo-4-(1-bromo-1,1,2,3,3,3-hexafluoropropan-2-yl)-6-(difluoromethoxy)aniline; quinoline-6-carbonyl chloride; With pyridine; In dichloromethane; for 5h; Reflux;

With lithium hydroxide; In tetrahydrofuran; water; at 18 - 30 ℃; for 2h;