3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Base Information

Chemical Name:3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester
CAS No.:764722-45-4
Molecular Formula:C₁₇H₂₃N₃O₆
Molecular Weight:365.386
Hs Code.:

3-(<i>tert</i>-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Synonyms:3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Suppliers and Price of 3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

There total 4 articles about 3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 7693-46-1
4-Nitrophenyl chloroformate

: 169750-01-0
(S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine

: 764722-45-4
3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: With TEA; In tetrahydrofuran; at 0 - 20 ℃; for 2h;
DOI:10.1016/j.bmcl.2006.06.049

Reference yield:

: 169750-00-9
(S)-1-benzyl-3-[[N-(t-butoxycarbonyl)]-N-methylamino]pyrrolidine

: 764722-45-4
3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / ammonium formate / Pd/C / ethanol / 2 h / Heating

2: 68 percent / TEA / tetrahydrofuran / 2 h / 0 - 20 °C

With TEA; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2006.06.049

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 764722-45-4
3-(tert-butoxycarbonyl-methyl-amino)-pyrrolidine-1-carboxylic acid 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / TEA / CH₂Cl₂ / 2 h / 20 °C

2: 76 percent / ammonium formate / Pd/C / ethanol / 2 h / Heating

3: 68 percent / TEA / tetrahydrofuran / 2 h / 0 - 20 °C

With TEA; ammonium formate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2006.06.049