(Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid

Base Information

• Chemical Name: (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid
• CAS No.: 1332232-70-8
• Molecular Formula: C₁₂H₁₃NO₄
• Molecular Weight: 235.24
• Mol file: 1332232-70-8.mol

Synonyms:(Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid

Chemical Property of (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid

There total 4 articles about (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate (930117-83-2) → (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid (1332232-70-8)

Guidance literature:

4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate; With sodium hydroxide; In methanol; at 20 ℃; for 2h; Reflux;

With sulfuric acid; In tert-butyl methyl ether; water; for 1h; pH=2.5;

DOI:10.1021/op200129m

Reference yield:

4-(hydroxylmethyl)benzaldehyde (52010-97-6) → (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid (1332232-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium acetate; acetic anhydride / ethyl acetate / Reflux

2.1: sodium hydroxide / methanol / 2 h / 20 °C / Reflux

2.2: 1 h / pH 2.5

With sodium acetate; acetic anhydride; sodium hydroxide; In methanol; ethyl acetate; 1.1: Erlenmeyer-Plochl azlactone and amino acid synthesis;

DOI:10.1021/op200129m

Reference yield:

1,4-bis(hydroxymethyl)benzene diacetate (14720-70-8) → (Z)-2-(acetylamino)-3-[4-(hydroxymethyl)phenyl]propenoic acid (1332232-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ethyl acetate / 18 h / 93 - 95 °C

2.1: sodium hydroxide / methanol / 2 h / 20 °C / Reflux

2.2: 1 h / pH 2.5

With sodium hydroxide; In methanol; ethyl acetate;

DOI:10.1021/op200129m

upstream raw materials:

4-[(Z)-(2-methyl-5-oxo-1,3-oxazol-4(5H)-ylidene)methyl]benzyl acetate

1,4-bis(hydroxymethyl)benzene diacetate

terephthalaldehyde,

4-(hydroxylmethyl)benzaldehyde