4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate

Base Information

• Chemical Name: 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate
• CAS No.: 1192797-40-2
• Molecular Formula: C₁₇H₂₅NO₃S
• Molecular Weight: 323.456
• Mol file: 1192797-40-2.mol

Synonyms:4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate

Chemical Property of 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate

There total 4 articles about 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate (1192797-38-8) + tiolacetic acid (507-09-5) → 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate (1192797-40-2)

Guidance literature:

tiolacetic acid; With potassium tert-butylate; In N,N-dimethyl-formamide;

4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1071/CH09308

Reference yield:

4-(4-nitrophenyl)-1-butanol (79524-20-2) → 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate (1192797-40-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: palladium on carbon; hydrogen

2.1: tetrahydrofuran / 24 h / 80 °C / Inert atmosphere

3.1: triethylamine / dichloromethane

4.1: potassium tert-butylate / N,N-dimethyl-formamide

4.2: 48 h / 20 °C

With palladium on carbon; potassium tert-butylate; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1071/CH09308

Reference yield:

tert-butyl 4-(4-hydroxybutyl)phenylcarbamate (1192797-36-6) → 4-[4-(tert-butoxycarbonylamino)phenyl]butyl ethanethioate (1192797-40-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane

2.1: potassium tert-butylate / N,N-dimethyl-formamide

2.2: 48 h / 20 °C

With potassium tert-butylate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1071/CH09308

upstream raw materials:

4-[4-(tert-butoxycarbonylamino)phenyl]butyl methanesulfonate

tiolacetic acid

tert-butyl 4-(4-hydroxybutyl)phenylcarbamate

4-(p-aminophenyl)butanol

Downstream raw materials:

4-(4-aminophenyl)butyl ethanethioate