(R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol>

Base Information

• Chemical Name: (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol>
• CAS No.: 223704-16-3
• Molecular Formula: C₂₆H₃₈N₂O₆S₂
• Molecular Weight: 538.73

Synonyms:(R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol>

Chemical Property of (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol>

Chemical Property:

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Technology Process of (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol>

There total 6 articles about (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol> which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(R,R)-1,2-bis(tosylamino)cyclohexane (143585-47-1) + 1-bromo-3-propanol (627-18-9) → (1'R,2'R)-N-(3-hydroxypropyl)-N-<2-(p-toluenesulphonylamino)cyclohexyl>-p-toluenesulphonamide + (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol> (223704-16-3)

Guidance literature:

With tetrabutyl-ammonium chloride; potassium carbonate; In toluene; at 70 ℃; for 48h;

DOI:10.1002/ejoc.200600234

Reference yield:

(R,R)-1,2-bis(tosylamino)cyclohexane (143585-47-1) → (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol> (223704-16-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 11 percent / K₂CO₃ / acetonitrile / 48 h / 70 °C

2: trifluoroacetic acid / CH₂Cl₂; methanol

With potassium carbonate; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1002/ejoc.200600234

Reference yield:

C64H66N2O6S2 (852043-14-2) → (R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulfonylamino)propan-1-ol> (223704-16-3)

Guidance literature:

With trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1002/ejoc.200600234

upstream raw materials:

(R,R)-1,2-bis(tosylamino)cyclohexane

1-bromo-3-propanol

C₆₄H₆₆N₂O₆S₂

(1R,2R)-1,2-dicyclohexane-1,2-diamine dihydrochloride

Downstream raw materials:

(R,R)-N,N'-(cyclohexane-1,2-diyl)bis-<3-(p-toluenesulphonylamino)propyl methanesulphonate>

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